Not with every mask. The AirSense 11 works with the ResMed nasal, nasal pillow, and full face masks on ResMed's official compatibility list, and with other vented masks your prescribing doctor recommends. Masks made only for the AirMini travel CPAP do not fit, so check yours on the
ResMed mask compatibility list. If you want heated tubing, the AirSense 11 works with the ClimateLineAir 11 or, if you use supplemental oxygen, the ClimateLineAir 11 Oxy; heated tubes made for the AirSense 10 are not compatible.