React Health G3 X Auto-CPAP machine, front view showing color screen, dial, and clear humidifier chamber

React Health G3 X Auto-CPAP Machine with Heated Humidifier

React Health | SKU:

G4600

React Health G3 X Auto-CPAP Machine with Heated Humidifier

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If you want sleep apnea therapy that just works without fiddling with settings, the React Health G3 X adjusts your pressure automatically through the night, giving you the support you need and not more. It is also the first standard-size foam-free PAP available in the U.S. (per React Health), built without the internal sound-abatement foam that has been on a lot of CPAP users' minds lately.

You get both auto-adjusting and fixed-pressure modes, gentle relief on every exhale, and a ramp that starts you low and eases up to your pressure while you fall asleep. This G4600 comes ready to use with the integrated heated humidifier and heated tubing, so the air reaches you warm with less water buildup in the hose, plus a built-in cellular modem that keeps your care team in the loop. It is backed by a 5-year warranty and is FSA/HSA eligible.

A prescription is required.

G3 X User Manual

G3 X Machine Overview

Returns Policy

Confirm your settings first: Your clinician programs your pressure range, Reslex level, and ramp. The G3 X requires a prescription, and therapy settings are set by your provider, not adjusted by you.
Mask fit matters most: A proper seal prevents leaks that can raise pressure and disturb sleep. If you see persistent leaks or red marks, try a different cushion size or mask style. Browse our CPAP masks.
Use ramp for a gentle start: If full pressure at bedtime feels strong, set ramp to Auto or up to 60 minutes so the device starts low and builds to your prescribed level while you fall asleep.
Give the auto algorithm time: Smart A adjusts your Auto min and Auto max using several effective treatment sessions, not a single night. Avoid overriding settings before several consistent nights of use.
Use distilled water only: Tap or filtered water leaves mineral deposits that shorten the chamber's life. Keep water below the max fill line (about 360 mL). Shop distilled water.
Get the most from heated tubing: Your G4600 includes integrated heated tubing. If condensation still collects, raise the tube heat or humidity level slightly. See more humidifiers and tubing.
Clean on a simple schedule: Clean the mask and humidifier chamber daily and the tubing weekly with mild soap and warm water. Do not use ozone or UV cleaners, since that voids the 5-year warranty. Find CPAP cleaning supplies.
Replace filters on time: Replace the reusable air filter about every 6 months (clean it as needed before that). If you use the optional disposable ultra-fine filter, replace it about every 2 weeks. Shop replacement filters.
When to contact your clinician: Reach out if therapy does not feel effective, if you wake with headaches, if mask leaks increase, or if the device shows a persistent alert. The on-screen iCode gives your provider a quick compliance summary.

If you want sleep apnea therapy that just works without fiddling with settings, the React Health G3 X adjusts your pressure automatically through the night, giving you the support you need and not more. It is also the first standard-size foam-free PAP available in the U.S. (per React Health), built without the internal sound-abatement foam that has been on a lot of CPAP users' minds lately.

You get both auto-adjusting and fixed-pressure modes, gentle relief on every exhale, and a ramp that starts you low and eases up to your pressure while you fall asleep. This G4600 comes ready to use with the integrated heated humidifier and heated tubing, so the air reaches you warm with less water buildup in the hose, plus a built-in cellular modem that keeps your care team in the loop. It is backed by a 5-year warranty and is FSA/HSA eligible.

A prescription is required.

See Product Details

React Health G3 X Auto-CPAP Machine with Heated Humidifier

$873.00

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Everything you need to know about the g3x

If the recent foam recalls left you wary, the G3 X is built without the internal sound-abatement foam, and React Health introduces it as the first standard-size foam-free PAP available in the U.S. It still runs quietly, around 28 dB(A) per the manufacturer, so it is easy to sleep next to.

You should not have to think about pressure settings. In auto mode, the Smart A feature reads your breathing over several nights and fine-tunes your range, so therapy stays comfortable as your needs change. Prefer a set pressure? It runs in fixed CPAP mode too.

Dry air is one of the most common reasons people give up on CPAP. This G4600 includes the integrated heated humidifier and heated tubing, so the air reaches you warm and you see less water buildup (rainout) in the hose. Use distilled water to keep the chamber clean.

React Health G3 X Auto-CPAP Machine with Heated Humidifier

First Standard-Size Foam-Free PAP in the U.S.

React Health introduces the G3 X as the first standard-size PAP available in the U.S. built without polyurethane sound-abatement foam, removing concerns about foam degrading over time. It still operates at about 28 dB(A) at 10 hPa, per the manufacturer.

Smart A Custom Pressure Response

In AutoCPAP mode, Smart A fine-tunes the auto algorithm using a rolling set of effective treatment sessions (at least 4 hours of use with a controlled leak under 90 L/min). It reviews the 50th and 95th percentile pressures to adjust your Auto min and Auto max over time.

SmartC for Fixed CPAP Mode

In CPAP mode, the SmartC algorithm adjusts the treatment pressure in response to your respiratory events. Together with Smart A in AutoCPAP mode, the G3 X covers both fixed and auto-adjusting therapy within your prescribed range of 4 to 20 cmH2O.

Proven Algorithm in Independent Bench Testing

React Health reports that, in an independent bench study, the auto-adjusting algorithm demonstrated accurate identification of obstructive respiratory events. Your clinician sets the mode and pressure limits that the algorithm works within.

Reslex Exhalation Pressure Relief

Reslex reduces pressure during exhalation so breathing out against the airflow feels more comfortable. It is enabled by your clinician at three levels (1, 2, or 3); higher levels mean more relief on the exhale.

Ramp for an Easier Start

The ramp feature starts therapy at a lower pressure and rises gradually to your prescribed level while you fall asleep. Set it to Auto or any duration from 0 to 60 minutes. Your clinician configures the starting pressure.

Integrated Heated Humidifier and Heated Tubing

The G4600 includes the integrated heated humidifier (Off, Auto, levels 1 to 5; about 360 mL) and integrated heated tubing (heat levels Off to 5). Heated tubing warms the air to your mask to reduce condensation (rainout). Use distilled water only.

React Health Connect Cloud and Patient App

The built-in cellular modem sends usage and performance data to your care team through the React Health Connect cloud platform, which includes a patient app for direct communication with your provider. No Wi-Fi is required for therapy or data.

Multiple Data Options

The G3 X offers built-in 4G cellular (included in this configuration), QR code, and SD card data access, plus on-screen iCode and iCode QR+ compliance codes and resupply reminders, so therapy data stays accessible even where connectivity is limited.

3.5-Inch Color LCD with Knob and Bedside Clock

The front panel uses a 3.5-inch color display for therapy data, alerts, and settings, navigated with a control knob plus Start/Standby and Home buttons. The screen also shows a bedside clock while the device is in standby.

Standard 22 mm Outlet, Compatible With Most Masks

The air outlet is a standard 22 mm conical connection (ISO 5356-1 compliant), compatible with nasal, nasal pillow, and full face CPAP masks. Tubing inner diameter is 19 mm and length is 6 ft (1.83 m).

Filters, Latex-Free Parts, and Maintenance

The G3 X uses a reusable air filter (replace about every 6 months, clean as needed) with an optional disposable ultra-fine filter (replace about every 2 weeks). All parts are natural rubber latex free. Do not use ozone cleaners, which voids the warranty.

Rated 3.0 out of 5 based on 1 customer review.

Some reviews on this page were submitted by customers who received an incentive, such as a discount code, in exchange for their feedback.

5 Tips for Selecting a CPAP Mask

Start with Our Mask Finder Quiz Get a personalized recommendation based on your needs—it only takes 5 minutes!
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FAQs

Yes. U.S. federal law restricts this device to sale by or on the order of a physician. You will need to provide a valid CPAP prescription before your order can be fulfilled. Your prescription should specify the therapy mode (CPAP or APAP) and your pressure settings.

React Health introduces the G3 X as the first standard-size PAP available in the U.S. built without polyurethane sound-abatement foam. Removing that foam eliminates concerns about the material degrading over time. The device still operates quietly, at about 28 dB(A) at 10 hPa per the manufacturer.

Yes, it supports both modes. In fixed CPAP mode it delivers a constant pressure set by your clinician (adjusted by the SmartC algorithm to your events). In AutoCPAP mode, the Smart A algorithm adjusts pressure automatically in response to your breathing events. Your clinician selects the mode and configures the settings.

In AutoCPAP mode, Smart A fine-tunes the auto algorithm using a rolling set of effective treatment sessions, defined as at least 4 hours of use with a controlled leak (under 90 L/min). It reviews the 50th and 95th percentile pressures to decide where your Auto min and Auto max should be adjusted, so therapy adapts gradually over time.

The therapeutic pressure range is 4 to 20 cmH2O, adjustable in 0.5 cmH2O increments. Under single-fault conditions the maximum limited pressure is 30 cmH2O or less. Your clinician programs the minimum and maximum pressures for your therapy.

Yes. The G3 X has an integrated heated humidifier built into the device, not a separate add-on. Humidity can be set to Off, Auto, or levels 1 through 5. The water chamber holds about 360 mL of distilled water to the max fill line.

Yes. This G4600 is the configuration with both a cellular modem and integrated heated tubing. The integrated heated tube keeps the air at a consistent temperature from the machine to your mask, which helps reduce condensation (rainout) on cold nights. Package contents can vary by configuration, so check your order details or reach out to us to confirm exactly what ships in your kit.

The G3 X uses a standard 22 mm conical air outlet (ISO 5356-1 compliant), which is compatible with most CPAP masks, including nasal masks, nasal pillow masks, and full face masks. Browse compatible masks at /collections/cpap-masks.

At a working pressure of 10 hPa, the device has a sound pressure level of 28 dB(A), per the manufacturer's published specifications (ISO 4871:1996). Actual noise in use will vary with mask fit and room conditions.

No Wi-Fi is required to deliver therapy or to store data. The G4600 includes a built-in cellular modem that sends usage and performance data to your care team through the React Health Connect cloud platform, which also has a patient app for direct communication with your provider. The device also supports SD card and QR code data access, plus on-screen iCode and iCode QR+ compliance codes.

Yes. The React Health G3 X is FSA/HSA eligible, so you can use your flexible spending account or health savings account funds toward your purchase. Dream Now, Pay Later financing is also available through Sleeplay.

The G3 X comes with a 5-year limited manufacturer warranty from React Health, with an expected service life of 5 years from the first date of use. Keep your proof of purchase and review the full warranty terms in the user manual.

React Health confirms the G3 X meets FAA requirements (RTCA DO-160) for all phases of air travel, so you can bring it as carry-on medical equipment. Some airlines do not count medical devices toward carry-on limits, but verify with your airline before traveling. For battery or DC power options, see /collections/power-solutions.

Clean the humidifier water chamber daily and let it air dry. Replace the reusable air filter about every 6 months, and the optional disposable ultra-fine filter about every 2 weeks. For your mask and tubing, follow the cleaning instructions in their own user guides. Do not use ozone-based cleaners on this device, since the manufacturer warns that ozone or other methods it does not recommend can void your warranty. Cleaning supplies are at /collections/cpap-cleaning-supplies.

It is normal to feel an adjustment period during the first one to two weeks. The ramp feature (up to 60 minutes) lets pressure build gradually while you fall asleep. Auto On starts therapy when you breathe into the mask, and Auto Off stops it when you remove the mask. If discomfort persists, contact your clinician before stopping therapy.

No, they are related but different machines from the same manufacturer. React Health (formerly 3B Medical, the maker of the Luna line) still lists the Luna G3 as a separate device, while the G3 X is the newer generation: the first standard-size PAP sold in the U.S. built without polyurethane sound-abatement foam. The G3 X keeps the familiar format, including the integrated heated humidifier, 4 to 20 cmH2O pressure range, and cellular data options, and adds the foam-free design plus the Smart A auto-adjusting algorithm. If you searched for a Luna G3X or 3B Medical G3, this is the current model that replaces those listings.

Yes. The G3 X connects to React Health Connect, the manufacturer's cloud platform, through its built-in cellular modem, so your therapy data uploads automatically with no Wi-Fi setup. React Health Connect includes a patient app where you can view your usage summaries and share data with your care team, and the device also supports SD card and QR code uploads plus on-screen iCode and iCode QR+ compliance codes if you prefer not to use the app at all.

Brand	React Health
Model / Item #	G4600 (Cellular Modem with Heated Tubing)
Device Type	CPAP / Auto-CPAP (APAP)
Therapy Modes	Fixed CPAP and AutoCPAP
Foam-Free	Yes (first standard-size foam-free PAP in the U.S., per React Health)
Pressure Range	4-20 cmH2O (0.5 cmH2O increments)
Max Limited Pressure	30 cmH2O or less (single fault)
Pressure Adjustment	Smart A (AutoCPAP), SmartC (CPAP)
Exhalation Relief	Reslex, clinician-enabled (levels 1-3)
Ramp	Auto or 0-60 minutes
Humidifier	Integrated heated (Off / Auto / levels 1-5), included
Water Chamber Capacity	About 360 mL (to max fill line)
Heated Tubing	Integrated heated tubing included (heat Off/1-5)
Tubing	19 mm ID, 6 ft (1.83 m); standard 22 mm ISO outlet
Sound Level	28 dB(A) sound pressure at 10 hPa (per manufacturer)
Display	3.5-inch color LCD with control knob
Connectivity	Built-in 4G cellular (included), QR code, SD card
Cloud Platform	React Health Connect (with patient app)
Filters	Reusable air filter + optional disposable ultra-fine filter
Power Supply	AC 100-240 V, 50/60 Hz
Dimensions	10.4 x 5.7 x 4.5 in (265 x 145 x 114 mm)
Weight	3.75 lb (1.7 kg)
Max Operating Altitude	2,300 m
Materials	Natural rubber latex free
Air Travel	Meets FAA requirements (RTCA DO-160), per React Health
Patient Range	Adults over 66 lb (30 kg)
Prescription Required	Yes
Classification	Class II, Type BF, IP22; HCPCS E0601
Expected Service Life	5 years
Warranty	5-year limited manufacturer warranty
Included in Box	G3 X device, integrated heated humidifier with water chamber, integrated heated tubing, cellular modem, power adapter, power cord, reusable air filter, carrying case, user guide

React Health G3 X Auto-CPAP Machine with Heated Humidifier

60-Night Guarantee

Free Shipping Over $50

5 Year Warranty

Unlimited Support

HSA/FSA Approved

Price Match Guarantee

Overview

Guide and Resources

Important Tips

What’s Included

Everything you need to know about the g3x

Foam-Free, One Less Worry

Pressure That Adjusts to You

Comfort Built In: Humidifier and Heated Tubing

First Standard-Size Foam-Free PAP in the U.S.

Smart A Custom Pressure Response

SmartC for Fixed CPAP Mode

Proven Algorithm in Independent Bench Testing

Reslex Exhalation Pressure Relief

Ramp for an Easier Start

Integrated Heated Humidifier and Heated Tubing

React Health Connect Cloud and Patient App

Multiple Data Options

3.5-Inch Color LCD with Knob and Bedside Clock

Standard 22 mm Outlet, Compatible With Most Masks

Filters, Latex-Free Parts, and Maintenance

5 Tips for Selecting a CPAP Mask

Start with Our Mask Finder Quiz Get a personalized recommendation based on your needs—it only takes 5 minutes!

Match Your Sleep Style Get a personalized recommendation based on your needs—it only takes 5 minutes!

Think About Comfort Get a personalized recommendation based on your needs—it only takes 5 minutes!

Try Any Mask for 60 Days—Risk-Free! Get a personalized recommendation based on your needs—it only takes 5 minutes!

Mind the Magnets Get a personalized recommendation based on your needs—it only takes 5 minutes!

Not sure which machine is best for you?

FAQs

Do I need a prescription to buy the React Health G3 X?

What does foam-free mean, and is the G3 X really the first?

Does the G3 X do both fixed CPAP and Auto-CPAP (APAP)?

How does the Smart A pressure response work?

What is the pressure range of the G3 X?

Is a humidifier included with the G3 X?

Does this G4600 come with a heated breathing tube?

What CPAP masks are compatible with the G3 X?

How quiet is the React Health G3 X?

How does data and connectivity work? Does it need Wi-Fi?

Is the G3 X FSA or HSA eligible?

What warranty does the G3 X carry?

Can I use the G3 X on an airplane?

How do I clean and maintain the G3 X?

What should I expect during the first few nights of therapy?

Is the React Health G3 X the same as the Luna G3?

Is there an app for the React Health G3 X?

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